No additive effect of combining sumatriptan and olcegepant in the GTN mouse model of migraine.

Charlotte ErnstsenSarah L ChristensenJes OlesenDavid M Kristensen

Published in: Cephalalgia : an international journal of headache (2020)

Combining olcegepant and sumatriptan did not have an additive effect compared to single-drug treatment in this study. Triptan-gepant combinations will therefore most likely not improve migraine treatment. Nevertheless, further studies are necessary, and combinations should also be examined in patients with migraine.

Keyphrases

mouse model
combination therapy
replacement therapy
smoking cessation
case control