Institutional review board perspectives on obligations to disclose genetic incidental findings to research participants.

Catherine GliwaIlana R YurkiewiczLisa Soleymani Lehmann Sara Chandros HullNathan JonesBenjamin E Berkman

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)

IRBs are actively engaged with GIFs but have not yet reached consensus. Respondents were uncomfortable with arguments that could be used to limit an obligation to return GIFs. This could indicate that IRBs are providing some of the impetus for the trend toward returning GIFs, although questions remain about the relative contribution of other stakeholders.Genet Med 18 7, 705-711.

Keyphrases

genome wide
clinical practice
copy number
gene expression
dna methylation