Gaditanone, a Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from Euphorbia gaditana.
M Eugenia Flores-GiubiMaría J Durán-PeñaJosé M Botubol-AresFelipe Escobar-MontañoDavid ZorrillaAntonio J Macías-SánchezRosario Hernández-GalánPublished in: Journal of natural products (2017)
A novel diterpenoid, gaditanone (2), which possesses an unprecedented 5/6/4/6-fused gaditanane tetracyclic ring skeleton, and a new jatrophane (1) were isolated from the aerial parts of Euphorbia gaditana. The chemical structures and absolute configurations were determined by extensive spectroscopic NMR studies and ECD data analysis. A proposed biosynthetic pathway is presented for compound 2.