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A drug-drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5-lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.

Jane KnöchelVijender PandugaKarin NelanderMaria HeijerEva-Lotte LindstedtHodan AliMalin AurellHelena ÖdesjöPablo ForteKat ConnollyHans EricssonIain MacPhee
Published in: British journal of clinical pharmacology (2024)
Atuliflapon is a weak inhibitor of CYP3A4; this was confirmed by the validated PBPK model. This weak inhibition is predicted to have a minor PK effect on CYP3A4 metabolized drugs.
Keyphrases
  • drug induced
  • signaling pathway
  • adverse drug
  • amino acid
  • small molecule
  • electronic health record