Cells on lockdown: long-term consequences of CDK4/6 inhibition.
Alexis R BarrSarah E McClellandPublished in: The EMBO journal (2022)
Inhibition of cyclin-dependent kinases Cdk4/6 is emerging as a useful anti-proliferative chemotherapy, but it remains unclear how durable inhibition of cancer cell proliferation is achieved to promote a long-lasting response in patients, or how toxicity is limited to cancer cells with minimal side effects. Two recent papers in The EMBO Journal investigating senescence induction following prolonged Cdk4/6 inhibitor treatment now reveal important insights into ways to increase anti-tumour effects of Cdk4/6 inhibition and to reduce therapy-induced side effects of senescence induction.
Keyphrases
- cell cycle
- cell proliferation
- end stage renal disease
- dna damage
- endothelial cells
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- squamous cell carcinoma
- genome wide
- high glucose
- single cell
- radiation therapy
- gene expression
- patient reported outcomes
- mesenchymal stem cells
- diabetic rats
- stress induced
- pi k akt
- drug induced
- cell death
- smoking cessation