Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex.
Sirui JiangPriya NandyWenzhang WangXiaopin MaJeffrey HsiaChunyu WangZhenlian WangMengyue NiuSandra L SiedlakSandy TorresHisashi FujiokaYing XuHyoung-Gon LeeGeorge PerryJun LiuXiongwei ZhuPublished in: Molecular neurodegeneration (2018)
Overall, our findings indicate that impaired mitochondrial fission and fusion balance can cause many of the neurodegenerative changes and eventual neuron loss that characterize AD in the hippocampus and cortex which makes it a potential target for treatment strategies for AD.