Weight gain among treatment-naïve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.
Kassem BourgiCathy A JenkinsPeter F RebeiroFrank PalellaRichard D MooreKeri N AltoffJohn GillCharles S RabkinStephen J GangeMichael A HorbergJoseph MargolickJun LiCherise WongAmanda WilligViviane D LimaHeidi M CraneJennifer ThorneMichael SilverbergGregory KirkWilliam C MathewsTimothy R SterlingJordan LakeJohn R Koethenull nullPublished in: Journal of the International AIDS Society (2020)
PWH initiating INSTI-based regimens gained, on average, more weight compared to NNRTI-based regimens. This phenomenon may reflect heterogeneous effects of ART agents on body weight regulation that require further exploration.