Effect of Functional Nanoporous TiO 2 Film Obtained on Ti6Al4V Implant Alloy to Improve Resistance in Biological Solution for Inflammatory Conditions.
Lidia BeneaAnca Ravoiu LupuIulian BounegruPetrica VizureanuPublished in: International journal of molecular sciences (2023)
The metallic titanium-based biomaterials are sensitive to corrosion-induced degradation in biological fluids in the presence of inflammatory conditions containing reactive oxygen species (ROS). Excess ROS induces oxidative modification of cellular macromolecules, inhibits protein function, and promotes cell death. In addition, ROS could promote implant degradation by accelerating the corrosive attack of biological fluids. The functional nanoporous titanium oxide film is obtained on titanium alloy to study the effect on implant reactivity in biological fluid with reactive oxygen species such as hydrogen peroxide, which are present in inflammations. The TiO 2 nanoporous film is obtained by electrochemical oxidation at high potential. The untreated Ti6Al4V implant alloy and nanoporous titanium oxide film are comparatively evaluated for corrosion resistance in biological solution by Hank's and Hank's doped with hydrogen peroxide by electrochemical methods. The results showed that the presence of the anodic layer significantly improved the resistance of the titanium alloy to corrosion-induced degradation in biological solutions under inflammatory conditions.
Keyphrases
- hydrogen peroxide
- reactive oxygen species
- cell death
- nitric oxide
- dna damage
- room temperature
- oxidative stress
- soft tissue
- quantum dots
- metal organic framework
- gold nanoparticles
- reduced graphene oxide
- high glucose
- cell proliferation
- drug induced
- cell cycle arrest
- small molecule
- high resolution
- protein protein
- amino acid
- label free