Frequency of Pathogenic Germline Mutations in Early and Late Onset Familial Breast Cancer Patients Using Multi-Gene Panel Sequencing: An Egyptian Study.
Auhood NassarAbdel Rahman N ZekriMahmoud M KamelMostafa H ElberryMai M LotfyMohamed G SeadawyZeinab K HassanHany K SolimanAhmed M LymonaAmira Salah El-Din YoussefPublished in: Genes (2022)
Multi-gene panel sequencing was used to detect the deleterious mutations associated with familial BC, which in turns mitigate the essential need for implementing next generation sequencing technologies in precision oncology to identify cancer predisposing genes. Moreover, identifying DNA repair gene mutations, with focus on non-BRCA genes, might serve as candidates for targeted therapy and will be increasingly used in precision oncology.
Keyphrases
- dna repair
- genome wide identification
- genome wide
- copy number
- dna damage
- palliative care
- genome wide analysis
- transcription factor
- single cell
- dna methylation
- early onset
- dna damage response
- papillary thyroid
- squamous cell
- quality improvement
- gene expression
- oxidative stress
- lymph node metastasis
- circulating tumor cells