Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study.
Anke HülsCatherine J WedderburnNynke A GroenewoldNicole GladishMeaghan J JonesNastassja KoenJulia L MacIsaacDavid Tse Shen LinKatia E RamadoriMichael P EpsteinKirsten Ann DonaldMichael S KoborHeather J ZarDan J SteinPublished in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)
Differential DNAm from cord blood and increased neonatal caudate volumes were independently associated with severe neurodevelopmental delay at 2 years of age. These findings suggest that neurobiological signals for severe developmental delay may be detectable in very early life.