Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.
Tomotsune AmekuYuto YoshinariMichael J TexadaShu KondoKotaro AmezawaGoro YoshizakiYuko Shimada-NiwaRyusuke NiwaPublished in: PLoS biology (2018)
Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication.
Keyphrases
- stem cells
- induced apoptosis
- drosophila melanogaster
- cell proliferation
- signaling pathway
- high glucose
- cell therapy
- cell cycle arrest
- diabetic rats
- drug induced
- aedes aegypti
- mesenchymal stem cells
- dna repair
- endoplasmic reticulum stress
- bone marrow
- oxidative stress
- endothelial cells
- cell cycle
- risk assessment
- life cycle