Subphenotypes of nonsteroidal antiinflammatory disease-exacerbated respiratory disease identified by latent class analysis.
Natalia Celejewska-WójcikKrzysztof WójcikMaria Ignacak-PopielAdam ĆmielKatarzyna TyrakAnna GieliczAleksander KaniaPaweł NastałekMarek SanakLucyna MastalerzPublished in: Allergy (2020)
LCA revealed three distinct NERD subphenotypes. Our results support a more complex pathobiology of aspirin hypersensitivity. Considering NERD heterogeneity, the relationship between inflammatory pathways and clinical manifestations of asthma may lead to more individualized treatment in difficult to treat patients in the future.
Keyphrases
- ejection fraction
- newly diagnosed
- single cell
- low dose
- chronic obstructive pulmonary disease
- oxidative stress
- prognostic factors
- type diabetes
- cardiovascular disease
- cardiovascular events
- coronary artery disease
- drug induced
- patient reported outcomes
- antiplatelet therapy
- acute coronary syndrome
- percutaneous coronary intervention