Identification of Reg3β-producing cells using IL-22-stimulated enteroids.

Mika SatoAkihiko InabaKen IwatsukiYuki SaitoMiki TadaishiMakoto ShimizuKazuo Kobayashi-Hattori

Published in: Bioscience, biotechnology, and biochemistry (2019)

Reg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of Reg3β. IL-22 also increased the mRNA levels of CD133 (a transit-amplifying cell marker) and lysozyme (a Paneth cell marker). Immunohistochemistry showed partial colocalization of Reg3β- and lysozyme-positive cells, suggesting that Paneth cells are one of Reg3β-producing cells.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
stem cells
small molecule
binding protein
protein protein