Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of N -(2-iodo-aryl) acrylamide.

Guangzhu WangChaoren ShenXinyi RenKaiwu Dong

Published in: Chemical communications (Cambridge, England) (2022)

A Ni/( S , S )-BDPP-catalyzed intramolecular Heck cyclization of N -(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.

Keyphrases

room temperature
metal organic framework
transition metal
fluorescent probe
energy transfer
ionic liquid
solid state