Combined genetic influences on episodic memory decline in older adults without dementia.

Of the individual genes, only APOE was associated with cognitive performance; ε4 carriers showed lower perceptual speed performance and faster category fluency decline. A cumulative score, combining APOE, BDNF, KIBRA and CLSTN2, was associated with faster cognitive decline that was specific to the episodic memory domain (regression coefficient -0.064, p < .01). Similar results were obtained for a score not including APOE. Conclusions: Results suggest a benefit of investigating the combined influence of polymorphisms related to specific mechanistic factors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).