A single locus determines praziquantel response in Schistosoma mansoni .

Frédéric D ChevalierWinka Le Clec'hMatthew BerrimanTimothy J C Anderson

Published in: bioRxiv : the preprint server for biology (2023)

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information.

Keyphrases

genome wide association study
genome wide
copy number
dna methylation
mass spectrometry
social media
electronic health record