Organ Protection by Caloric Restriction Depends on Activation of the De Novo NAD+ Synthesis Pathway.
Martin Richard SpäthK Johanna R Hoyer-AlloLisa SeufertMartin HöhneChristina LucasTheresa BockLea IsermannSusanne BrodesserJan-Wilm LackmannKatharina KieferFelix Carlo KoehlerKatrin BohlMichael IgnarskiPetra SchillerMarc JohnsenTorsten KubackiFranziska GrundmannThomas BenzingAleksandra TrifunovicMarcus KrügerBernhard SchermerVolker BurstRoman-Ulrich MüllerPublished in: Journal of the American Society of Nephrology : JASN (2023)
CR induces the de novo NAD+ synthesis pathway in the context of IRI and is essential for its full nephroprotective potential. Differential protein acetylation may be the molecular mechanism underlying the relationship of NAD+, CR, and nephroprotection.
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