Reduced lateral occipital gray matter volume is associated with physical frailty and cognitive impairment in Parkinson's disease.
Yueh-Sheng ChenHsiu-Ling ChenCheng-Hsien LuMeng-Hsiang ChenKun-Hsien ChouNai-Wen TsaiChiun-Chieh YuPi-Ling ChiangWei-Che LinPublished in: European radiology (2018)
• Physical frailty in PD was associated with decreased GMV in the frontal and occipital cortices, while cognitive impairment was associated with decreased GMV in the frontal, temporal, and occipital cortices. • Physical frailty and cognitive impairment were both associated with decreased GMV in the lateral occipital cortex, which is part of the ventral object-based visual pathway. • Decreased GMV in the lateral occipital cortex may serve as a potential imaging biomarker for physical frailty and cognitive impairment in PD.