Evaluating the role of a fully automated SARS-CoV-2 antigen ECLIA immunoassay in the management of the SARS COV 2 pandemic on general population.
Mariarosa CartaMichela PascarellaAnna CappellettiMario RassuDavide GiavarinaPublished in: Diagnosis (Berlin, Germany) (2022)
Our study confirms the reliability of the fourth-generation antigen assay in recognizing negative samples. Conversely, sensitivity appears to be less reliable (68.0%) than reported in the literature. This could be due to a non-randomized study group: many swab samples were taken from patients with expected low viral load (hospitalized for COVID for more than 10-12 days or asymptomatic patients for epidemiological surveillance). The strong correlation of sensitivity and viral load could prove significant to track the infectiousness of infected people, as previous studies reported that a viral load of at least 10E6 copies of RNA/mL, corresponding to 25 CT, is the threshold of transmission of the disease.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- end stage renal disease
- coronavirus disease
- high throughput
- chronic kidney disease
- systematic review
- ejection fraction
- newly diagnosed
- computed tomography
- machine learning
- prognostic factors
- deep learning
- magnetic resonance imaging
- magnetic resonance
- patient reported outcomes
- sensitive detection
- quantum dots
- case control