Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice.

Frank Silva BezerraCamila de Oliveira RamosThalles de Freitas CastroNatália Pereira da Silva AraújoAna Beatriz Farias de SouzaAna Carla Balthar BandeiraGuilherme de Paula CostaChristiane Teixeira CartelleAndré TalvaniSílvia Dantas CangussúLaurent BrochardAkinori Cardozo Nagato

Published in: Intensive care medicine experimental (2019)

Our results offer new perspectives on the effects and the mechanism of exogenous surfactant in protecting the airway and lungs, in oxygen-rich lung microenvironment, against oxidative damage and aggravation of acute inflammation induced by hyperoxia.

Keyphrases

drug induced
liver failure
oxidative stress
diabetic rats
high glucose
stem cells
respiratory failure
high fat diet induced
mouse model
aortic dissection
type diabetes
hepatitis b virus
extracorporeal membrane oxygenation
childhood cancer
mechanical ventilation