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Visible-Light-Induced Decarboxylative Cyclization/Hydrogenation Cascade Reaction to Access Phenanthridin-6-yl(aryl)methanol by an Electron Donor-Acceptor Complex.

Wei ShiFang MaPinhua LiLei WangTao Miao
Published in: The Journal of organic chemistry (2020)
A novel and efficient visible-light-induced decarboxylative cyclization/hydrogenation cascade reaction of α-oxocarboxylic acids and 2-isocyanobiaryls has been developed. Without the need of any external photosensitizer, oxidant, and reductant, this method offers a mild and green approach for the synthesis of diverse alcohols in moderate to good yields. A mechanism indicated that an electron donor-acceptor complex-driven decarboxylation, radical addition/cyclization, and in situ photochemical reduction of ketones to alcohols could be involved in the reaction.
Keyphrases
  • visible light
  • solar cells
  • electron transfer
  • photodynamic therapy
  • high glucose
  • high intensity
  • energy transfer
  • diabetic rats
  • endothelial cells
  • drug induced
  • anti inflammatory