Impact of CYP1A2 genetic polymorphisms on pharmacokinetics of antipsychotic drugs: a systematic review and meta-analysis.

M Na TakuathungNutthiya HanprasertpongS TeekachunhateanNut Koonrungsesomboon

Published in: Acta psychiatrica Scandinavica (2018)

This study suggests that CYP1A2 genetic polymorphisms have no significant impact on the pharmacokinetics of CYP1A2-metabolized antipsychotic drugs. CYP1A2 genotyping may have no clinical implications for personalized dosing of CYP1A2-metabolized antipsychotic drugs.

Keyphrases

genome wide
drug induced
gene expression
dna methylation