Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes.
Daiane Barros Dias MendonçaRenata Ellen Costa SilvaFanny Palace-BerlCleusa Fh TakakuraSandra Regina C SoaresLucia Maria Almeida BrazLeoberto Costa TavaresJosé Angelo Lauletta LindosoPublished in: The journal of venomous animals and toxins including tropical diseases (2019)
Nitro-heterocyclic compounds have shown activity against promastigotes of L. amazonensis, at lower concentrations. However, improvement of compound scaffolds are needed to assist the elucidation of the mechanism of action and to achieve greater activity.