Targeted Therapies and Druggable Genetic Anomalies in Acute Myeloid Leukemia: From Diagnostic Tools to Therapeutic Interventions.

Published in: Cancers (2021)

Acute myeloid leukemia (AML) is a clonal disorder resulting from acquired somatic mutations in hematopoietic progenitor cells that lead to the dysregulation of differentiation and the proliferation of hematopoietic cells [...].

Keyphrases

acute myeloid leukemia
induced apoptosis
bone marrow
allogeneic hematopoietic stem cell transplantation
copy number
signaling pathway
cell cycle arrest
genome wide
oxidative stress
cell death
cell proliferation