Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality.

Filip Ottosson Einar SmithUlrika EricsonLouise BrunkwallMarju Orho-MelanderSalvatore Di SommaPaola AntoniniPeter M NilssonCéline FernandezOlle Melander

Published in: Diabetes care (2022)

We found that lean individuals with an obesity-related metabolome have an increased risk for type 2 diabetes and all-cause mortality compared with lean individuals with a healthy metabolome. Metabolomics may be used to identify hidden high-risk individuals to initiate lifestyle and pharmacological interventions.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
glycemic control
cardiovascular disease
physical activity
high fat diet induced
cardiovascular events
adipose tissue
bone mineral density
mass spectrometry
risk factors
skeletal muscle
current status
postmenopausal women