Characterisation of mobile colistin resistance genes (mcr-3 and mcr-5) in river and storm water in regions of the Western Cape of South Africa.
Yolandi SnymanAndrew C WhitelawJo M BarnesMotlatji R B MalobaMae Newton-FootPublished in: Antimicrobial resistance and infection control (2021)
The mcr-5.1 and mcr-3 colistin resistance gene variants were present in widely dispersed water sources in regions of the Western Cape. The mcr genes were only detected in water sampled downstream of and alongside communities, suggesting that their presence is driven by human influence/contamination. This is the first documentation of mcr-3 and mcr-5 gene variants in any setting in South Africa. Spill-over of these genes to communities could result in horizontal gene transfer to pathogenic bacteria, exacerbating the challenge of controlling multidrug resistant GNB infections.
Keyphrases
- south africa
- multidrug resistant
- escherichia coli
- klebsiella pneumoniae
- genome wide
- acinetobacter baumannii
- genome wide identification
- copy number
- gram negative
- drug resistant
- hiv positive
- genome wide analysis
- dna methylation
- endothelial cells
- drinking water
- gene expression
- pseudomonas aeruginosa
- transcription factor
- risk assessment
- climate change
- hepatitis c virus
- induced pluripotent stem cells
- men who have sex with men