Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide-induced impairment of sperm and fertility in mice.

Pengfei ZhuXingyu BiDan SuXiaoling LiBingbing ChenJuhua LiLijiang ZhaoYaoqing WangSuming XuXueqing Wu

Published in: Immunopharmacology and immunotoxicology (2024)

THL can improve sperm quality and hormonal balance in OA mice through the inhibition of NLRP3 inflammasome activation. Thus, THL holds promising potential as a therapeutic agent for OA.

Keyphrases

nlrp inflammasome
high fat diet induced
knee osteoarthritis
low dose
high glucose
diabetic rats
high dose
type diabetes
oxidative stress
polycystic ovary syndrome
insulin resistance
young adults
risk assessment
adipose tissue
human health
endothelial cells