Prediction of protein architectures involved in the signaling-pathway initiating sporulation in Firmicutes.

Similar to the report of Davidson et al. (PLoS Genet 14:1-33, 2018), we used Pfam profiles (El-Gebali et al. in Nucleic Acids Res 47:D427-32, 2019) defining each protein and the genomic context surrounding the query gene to predict probable orthologs of the Spo0 pathway in Firmicutes. We present in this note a collection of 325 Firmicutes species organized by phylogenetic class and classified as spore formers, non-spore formers or unknown spore phenotype based on published literature, for which we predicted probable orthologs defining the signal transduction pathway initiating sporulation.