Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling.

Yulin HeXingrong GuoTingyu LanJianbo XiaJinsong WangBei LiChunyan PengYue ChenXiang HuZhong Ji Meng

Published in: Stem cell research & therapy (2021)

hUC-MSC transplantation can improve liver function, the degree of fibrosis, and liver damage and promote liver repair in rats with ACLI or ACLF, mediated most likely by inhibiting Notch signaling and reversing the imbalance of the Stat1/Stat3 pathway.

Keyphrases

liver failure
cell proliferation
umbilical cord
mesenchymal stem cells
hepatitis b virus
oxidative stress
drug induced
stem cells
respiratory failure
acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation