Regulation of the PKD2 channel function by TACAN.

-permeable cation channel and is mutated in about 15% of human autosomal dominant polycystic kidney disease (ADPKD). Using the two-electrode voltage clamp (TEVC) with Xenopus oocytes, patch clamp with mammalian cells, zebrafish model, and molecular biology techniques, we here found that membrane protein TACAN forms a complex with PKD2 on the primary cilia of renal epithelial cell lines and acts as a novel inhibitor of the PKD2 function in vitro and in vivo. This article is protected by copyright. All rights reserved.