Integrating a Fundus Camera with High-Frequency Ultrasound for Precise Ocular Lesion Assessment.
Alfa RossiYushun ZengMojtaba RahimiTaeyoon SonMichael J HeifermanChen GongXin SunMohammad SoleimaniAli R DjalilianMark S HumayunQifa ZhouXincheng YaoPublished in: Biosensors (2024)
Ultrasound A-scan is an important tool for quantitative assessment of ocular lesions. However, its usability is limited by the difficulty of accurately localizing the ultrasound probe to a lesion of interest. In this study, a transparent LiNbO 3 single crystal ultrasound transducer was fabricated, and integrated with a widefield fundus camera to guide the ultrasound local position. The electrical impedance, phase spectrum, pulse-echo performance, and optical transmission spectrum of the ultrasound transducer were validated. The novel fundus camera-guided ultrasound probe was tested for in vivo measurement of rat eyes. Anterior and posterior segments of the rat eye could be unambiguously differentiated with the fundus photography-guided ultrasound measurement. A model eye was also used to verify the imaging performance of the prototype device in the human eye. The prototype shows the potential of being used in the clinic to accurately measure the thickness and echogenicity of ocular lesions in vivo.
Keyphrases
- magnetic resonance imaging
- high frequency
- contrast enhanced ultrasound
- ultrasound guided
- diabetic retinopathy
- oxidative stress
- high speed
- primary care
- healthcare
- optical coherence tomography
- magnetic resonance
- transcranial magnetic stimulation
- quantum dots
- risk assessment
- mass spectrometry
- convolutional neural network
- social media
- living cells
- health information
- fluorescent probe