Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells.

Yumeng ZhangJiaqi XuZhili RenYa MengWeiwei LiuLigong LuZhou ZhouGuokai Chen

Published in: Stem cell research & therapy (2021)

In this report, we revealed that nicotinamide promotes generation of pancreatic progenitors from hESCs through CK1 and ROCK inhibition. Furthermore, we discovered the novel role of CK1 in pancreatic cell fate determination.

Keyphrases

embryonic stem cells
cell fate
protein kinase
endothelial cells
single cell
induced pluripotent stem cells
mass spectrometry
high resolution
molecularly imprinted