Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis.

Fei ShaoXueying YangWei WangJuhong WangWei GuoXiaoli FengSusheng ShiQi XueShugeng GaoYibo GaoZhimin LuJie He

Published in: Cancer communications (London, England) (2019)

The elevated expression, promoter hypomethylation, and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer. PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers.

Keyphrases

papillary thyroid
squamous cell
dna methylation
gene expression
transcription factor
protein kinase
lymph node metastasis
childhood cancer
risk assessment
young adults
binding protein