The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating β-catenin.

Yujia ZhengZheng ZhouRan WeiChu XiaoHao ZhangTao FanBo ZhengChunxiang LiJie He

Published in: Journal of translational medicine (2022)

We found that PCBP1 inhibits LUAD development by upregulating DKK1 to inactivate the Wnt/β-catenin pathway. Our findings highlight the potential of PCBP1 as a promising therapeutic target.

Keyphrases

binding protein
cell proliferation
stem cells
risk assessment
signaling pathway
climate change