Multifunctional Cu 2 Se/F127 Hydrogel with SOD-like Enzyme Activity for Efficient Wound Healing.

As the first barrier to the external environment, the skin covers the entire surface area of the body. Heat, sharp objects and chemicals can damage the skin and cause wounds to form. Following skin damage, free radicals are secreted, which cause oxidative stress and inflammatory reactions that make wound healing difficult. In this study, copper-based nanozyme Cu 2 Se nanosheets (NSs) were synthesized by an anion-exchange strategy and applied to wounds with F127 hydrogel to investigate the healing effect of this nanozyme composite hydrogel on wounds. Cu 2 Se NSs have a large specific surface area, contain a large number of catalytic active centers, are simple to synthesize, require low reaction conditions and have a short synthesis cycle. In vitro experiments have shown that Cu 2 Se NSs possess superoxide dismutase (SOD)-like activity and nitrogen radical scavenging activity and promote angiogenesis and fibroblast migration. The doping of Cu 2 Se NSs into the F127 hydrogel did not have a significant effect on the properties of the hydrogel. This hybridized hydrogel not only adapts to the irregular and complex morphology of acute wounds but also prolongs the time of nanozyme action on the wound, thus promoting wound healing. Transcriptomic analysis further revealed the potential therapeutic mechanism of the Cu 2 Se/F127 hydrogel to promote acute wound healing. Animal experiments have shown that the Cu 2 Se/F127 hydrogel has good biosafety. The Cu 2 Se/F127 hydrogel provides an innovative idea for the development of hydrogel dressings for the treatment of acute wounds of the skin. This article is protected by copyright. All rights reserved.