Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia.
Jorge Antonio Elias Godoy CarlosKeli LimaJuan Luiz Coelho-SilvaRaquel de Melo Alves-PaivaNatália Cestari MorenoHugo Passos VicariFábio Pires de Souza SantosNelson HamerschlakLeticia Veras Costa-LotufoFabiola TrainaJoão Agostinho Machado-NetoPublished in: Cellular oncology (Dordrecht) (2020)
From our data we conclude that reversine reduces the viability of ALL cells by triggering multiple cell death mechanisms, including apoptosis, mitotic catastrophe, and autophagy. Our findings highlight reversine as a potential anticancer agent for ALL.