Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Postmenopausal Women.
Jessica L PetrickAndrea A FlorioXuehong ZhangAnne Zeleniuch-JacquotteJean Wactawski-WendeStephen K Van den EedenFrank Z StanczykTracey G SimonRashmi SinhaHoward D SessoCatherine SchairerLynn RosenbergThomas E RohanMark P PurdueJulie R PalmerMartha S LinetLinda M LiaoI-Min LeeJill KoshiolCari M KitaharaVictoria A KirshJonathan N HofmannChantal GuillemetteBarry I GraubardEdward GiovannucciJ Michael GazianoSusan M GapsterNeal D FreedmanLawrence S EngelDawn Qingqing ChongYu ChenAndrew T ChanPatrick CaronJulie E BuringGary BradwinLaura E Beane-FreemanPeter T CampbellKatherine A McGlynnPublished in: Hepatology (Baltimore, Md.) (2021)
This study provides evidence that higher levels of 4-dione may be associated with lower, and SHBG with higher, LC risk in women. However, this study does not support the hypothesis that higher estrogen levels decrease LC risk. Indeed, estradiol may be associated with an increased ICC risk.