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Feasibility of combining temsirolimus to vincristine, dactinomycin, cyclophosphamide, and vincristine and irinotecan chemotherapy for children with intermediate-risk rhabdomyosarcoma: A report from Children's Oncology Group.

Sara J IsraelsAmria QumseyaWei XueDouglas J HarrisonErin R RudzinskiSuzanne L WoldenRoshni DasguptaRajkumar VenkatramaniAbha A Gupta
Published in: Pediatric blood & cancer (2023)
/dose during VAC/VI chemotherapy was feasible and well tolerated. The efficacy of this regimen is currently being tested in a phase III randomized trial against VAC/VI chemotherapy alone in the ARST1431 trial.
Keyphrases
  • phase iii
  • locally advanced
  • open label
  • clinical trial
  • young adults
  • phase ii
  • double blind
  • low dose
  • study protocol
  • squamous cell carcinoma
  • radiation therapy
  • rectal cancer
  • chemotherapy induced
  • placebo controlled