Parenteral Prostanoids in Pediatric Pulmonary Arterial Hypertension: Start Early, Dose High, Combine.
Johannes M DouwesWillemijn Mh ZijlstraErika B RosenzweigMark-Jan PloegstraUsha S KrishnanMeindina G HaarmanMarcus T R RoofthooftDouwe PostmusHans L HillegeD Dunbar IvyRolf M F BergerPublished in: Annals of the American Thoracic Society (2021)
Early initiation of IV/SC prostanoids, higher doses of IV/SC prostanoids and combination with additional PAH-targeted therapy were associated with favorable outcome. Transition from IV/SC prostanoid therapy to oral or inhaled therapies is safe on the long-term in selected children, identified by reaching hemodynamic criteria for durable IV/SC prostanoid discontinuation while on IV/SC prostanoid therapy.