A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility.

Melissa SorosinaNadia BarizzoneFerdinando ClarelliSantosh AnandSara LupoliErika SalviEleonora ManganoRoberta BordoniTina RoostaeiElisabetta MasciaMiriam ZuccalàDomizia VecchioPaola CavallaSilvia SantoroLaura FerrèAlen Zollonull nullCristina BarlassinaDaniele CusiVittorio MartinelliGiancarlo ComiMaurizio LeoneMassimo FilippiNikolaos A PatsopoulosPhilip L De JagerGianluca De BellisFederica EspositoSandra D'AlfonsoFilippo Giovanni Martinelli Boneschi

Published in: Journal of neurology (2022)

No evidence of novel signal of association with MS specific for the Italian continental population has been found; nevertheless, two MS loci seems to play a relevant role, raising the interest to further investigations for TBKBP1 gene.

Keyphrases

multiple sclerosis
genome wide
copy number
mass spectrometry
ms ms
white matter
genome wide identification
dna methylation
transcription factor
genome wide association