Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-β1-miR29a in mice.
Xin-Yi XuYan DuXue LiuYilin RenYingying DongHong-Yu XuJin-Song ShiDianhua JiangXin XuLian LiZheng-Hong XuYan GengPublished in: Cell communication and signaling : CCS (2020)
Our data suggests TGF-β1-miR29a-Fstl1 regulatory circuit plays a key role in regulation the HSC activation and ECM production, and targeting Fstl1 may be a strategy for the treatment of liver fibrosis. Video Abstract.
Keyphrases
- liver fibrosis
- cell proliferation
- long non coding rna
- transforming growth factor
- long noncoding rna
- cancer therapy
- electronic health record
- transcription factor
- liver injury
- mouse model
- big data
- high fat diet induced
- epithelial mesenchymal transition
- type diabetes
- combination therapy
- drug induced
- artificial intelligence
- data analysis