Therapeutic Effects of Tofacitinib on Pristane-Induced Murine Lupus.

Jiayi Lin Yaqin Zhang Meihua Wang Yang Zhang Pin Li Yingping Cao Xuwei Yang

Published in: Archives of rheumatology (2022)

Tofacitinib can ameliorate glomerulonephritis and arthritis in a pristane-induced murine model of lupus. SOCS3 gene may be involved in the therapeutic mechanism of tofacitinib.

Keyphrases

rheumatoid arthritis
disease activity
systemic lupus erythematosus
high glucose
diabetic rats
ulcerative colitis
drug induced
endothelial cells
genome wide
copy number
transcription factor