Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H.

Devin M FergusonChristian A MalapitJames R BourMelanie S Sanford

Published in: The Journal of organic chemistry (2019)

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(P tBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

Keyphrases

highly efficient