Natural and Undetermined Sudden Death: Value of Post-Mortem Genetic Investigation.

Olallo SanchezÒscar CampuzanoAnna Fernández-FalguerasGeorgia Sarquella-BrugadaSergi CesarIrene MademontJesus MatesAlexandra Pérez-SerraMonica CollFerran PicoAnna IglesiasColoma TirónCatarina AllegueEsther CarroMaría Ángeles GallegoCarles Ferrer-CostaAnna HospitalNarcís BardaletJuan Carlos BorondoAlbert VingutElena ArbeloJosep BrugadaJosep CastellàJordi MedalloRamon Brugada

Published in: PloS one (2016)

Cardiac disease is the most important cause of sudden death, especially after the age of 40. Close to 10% of cases may remain unexplained after a complete autopsy investigation. Molecular autopsy may provide an explanation for a significant part of these unexplained cases. Identification of genetic variations enables genetic counseling and undertaking of preventive measures in relatives at risk.

Keyphrases

genome wide
copy number
left ventricular
gene expression
heart failure
single molecule