Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease.
Daniel H LeungSridevi DevarajNathan P GoodrichXinpu ChenDeepthi RajapaksheWen YeVictor AndreevCharles G MinardDanielle GuffeyJean P MollestonLee M BassSaul J KarpenBinita M KamathKasper S WangShikha S SundaramPhilip RosenthalPatrick McKiernanKathleen M LoomesM Kyle JensenSimon P HorslenJorge A BezerraJohn C MageeRobert M MerionRonald J SokolBenjamin L Shneidernull nullPublished in: Hepatology (Baltimore, Md.) (2022)
Endoglin, IL-8, and MMP-7 significantly correlate with increased LSM in children with BA, whereas CTGF inversely correlates with LSM in participants with A1AT; these biomarkers appear to enhance prediction of LSM beyond clinical tests. Future disease-specific investigations of change in these biomarkers over time and as predictors of clinical outcomes will be important.