Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major.

G CostanzoA NaselliM L ArpiT PiticchioR Le MoliA BelfioreFrancesco Frasca

Published in: Journal of endocrinological investigation (2024)

Our study shows that, in male patients with BTM, serum IGF-1 ≤ 50.0 ng/dl is a marker of vertebral fractures and it is predictive of a diagnosis of GHD.

Keyphrases

bone mineral density
pi k akt
binding protein
growth hormone
postmenopausal women
signaling pathway
cell proliferation
young adults
sickle cell disease