Plasma Exchange to Rescue Patients with Autoantibodies Against Type I Interferons and Life-Threatening COVID-19 Pneumonia.

Nicolas De ProstPaul BastardRomain ArrestierSlim FouratiMathieu MahévasSonia BurrelKarim DorghamGuy GorochovYacine Tandjaoui-LambiotteIname AzzaouiIgnacio FernandesAlain CombesJean-Laurent CasanovaArmand Mekontso-DessapCharles-Edouard Luyt

Published in: Journal of clinical immunology (2021)

PE efficiently removes autoantibodies against type I IFNs, including those detected in tracheal aspirates, without affecting anti-SARS-CoV-2 antibody levels, in patients with life-threatening COVID-19 pneumonia. The clinical benefit of PE in patients with autoantibodies against type I IFNs should be tested in a larger study.

Keyphrases

sars cov
systemic lupus erythematosus
coronavirus disease
respiratory syndrome coronavirus
respiratory failure
community acquired pneumonia