Orai-IGFBP3 signaling complex regulates high-glucose exposure-induced increased proliferation, permeability, and migration of human coronary artery endothelial cells.
Suwen BaiYuan WeiWenxuan HouYanHeng YaoJunwei ZhuXianyu HuWei ChenYinan DuWei HeBing ShenJuan DuPublished in: BMJ open diabetes research & care (2021)
Orais and IGFBP3 formed a signaling complex that mediated HCAEC proliferation during HG exposure in culture. Meanwhile, we also found that SOCE stimulates proliferation of HCAECs by regulating IGFBP3, thereby promoting the occurrence and progression of coronary atherosclerosis in diabetes. It is worth noting that our findings may shed new light on the mechanisms of increased proliferation in HCAECs in diabetes and suggest the potential value of SOCE and IGFBP3 as therapeutic targets for coronary atherosclerosis in individuals with diabetes.
Keyphrases
- endothelial cells
- high glucose
- coronary artery
- cardiovascular disease
- type diabetes
- signaling pathway
- glycemic control
- coronary artery disease
- pulmonary artery
- vascular endothelial growth factor
- risk assessment
- metabolic syndrome
- oxidative stress
- adipose tissue
- pulmonary hypertension
- pulmonary arterial hypertension
- weight loss
- diabetic rats
- aqueous solution