Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.
Qian YangWen-Ting CaiHuizi JinTian-Yi ShenJing YuPublished in: Oxidative medicine and cellular longevity (2022)
-induced cell stress model and blue LED-induced retinal light damage model. TXNIP transferred from the nucleus to the cytoplasm, activated NLRP3, and aggravated the retinal injury in both the cell stress model and the animal blue LED model. In contrast, Trx1 knockout promoted this process. This study revealed the possible role of the thioredoxin system in developing AMD while also providing newer insights for the future treatment of AMD.
Keyphrases
- inflammatory response
- mouse model
- single cell
- oxidative stress
- diabetic retinopathy
- diabetic rats
- cell proliferation
- cell therapy
- induced apoptosis
- magnetic resonance imaging
- stem cells
- magnetic resonance
- signaling pathway
- lipopolysaccharide induced
- toll like receptor
- lps induced
- heat stress
- smoking cessation
- contrast enhanced