Characterization of a transgenic mouse model of chronic conditional platelet depletion.

Leah M WuescherSharmeen NishatRandall G Worth

Published in: Research and practice in thrombosis and haemostasis (2019)

When compared to the gold standard of antibody-mediated depletion, PF4-DTR mice showed similar phenotypes and should be considered an important tool for examining the impact of thrombocytopenia over longer periods of time.

Keyphrases

mouse model
high fat diet induced
type diabetes
insulin resistance